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Giredestrant

Catalog No. T11399 CAS 1953133-47-5

Synonyms: GDC-9545

Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.

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Giredestrant, CAS 1953133-47-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 169.00
2 mg	In stock	$ 213.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 463.00
25 mg	In stock	$ 872.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 2,180.00
200 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 332.00

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Purity: 98.96%

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Storage & Solubility Information

Description	Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.
In vitro	The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile.Giredestrant (GDC-9545) is a novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes.

Synonyms	GDC-9545
Molecular Weight	522.55
Formula	C27H31F5N4O
CAS No.	1953133-47-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (191.37 mM), Sonication is recommended.

References and Literature

1. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Bioactive Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Nuclear Receptor Compound Library NO PAINS Compound Library

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Keywords

Giredestrant 1953133-47-5 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR ligand conformational inhibit non-steroidal anti-tumor GDC9545 GDC-9545 Inhibitor orally change GDC 9545 inhibitor

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