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Hypocrellin A

Catalog No. T5771 CAS 77029-83-5

Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.

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Hypocrellin A, CAS 77029-83-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 582.00
100 mg	In stock	$ 829.00
500 mg	In stock	$ 1,660.00

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Purity: 99.81%

Purity: 98.63%

Purity: 98%

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Description	Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.
In vitro	Treatment with Hypocrellin A(HA) resulted in a decrease in cell viability and migration in HCC cells.?Furthermore, ?HA decreased the YAP and TEAD protein levels of the Hippo pathway.?HA could potentiate OA's effect on HCC cells.?HA could inhibit the growth of HCC cells in darkness through Hippo-YAP signaling and HA combined with OA had a better effect than HA or OA alone.
Cell Research	Cells were seeded in 96-well plates at a density of 1*10^4 cells in a final volume of 100 μl and maintained in DMEM medium at 37℃ ?.?After cells were treated with different concentrations of HA (5, 10, 20, 40, 80 μM), 20 μl 5 mg/ml MTT solution were added to each well and incubated for 4 h in the incubator.?Then 150 μl DMSO were added to each well to dissolve the pellet, keep it in the dark for 15 min, and dissolve the crystal completely.?Automatic microplate reader measured at 490 nm optical density (OD value).?The experiment was repeated three times.?For combination test, cells were treated with 20 μM Hypocrellin A?and different?concentrations of OA(25,50,100, 200 μM) .

Molecular Weight	546.52
Formula	C30H26O10
CAS No.	77029-83-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mg/mL (4.57 mM)

References and Literature

1. Wang L , Wang J , Cao Y , et al. Molecular evidence for better efficacy of hypocrellin A and oleanolic acid combination in suppression of HCC growth[J]. European Journal of Pharmacology, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library TGF-beta/Smad Compound Library Inhibitor Library Anti-Parasitic Compound Library Anti-Cancer Active Compound Library Microbial Natural Product Library Anti-Infection Compound Library Anti-Fungal Compound Library Epigenetics Compound Library Bioactive Compounds Library Max

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Keywords

Hypocrellin A 77029-83-5 Chromatin/Epigenetic Cytoskeletal Signaling Microbiology/Virology Antibacterial PKC Parasite Bacterial inhibit Inhibitor Protein kinase C inhibitor

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