Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 222.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. |
In vitro | CA-4948 was previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models using cell lines OCI-LY3 and OCI-LY10[1]. |
In vivo | CA-4948 has antitumor activity in ABC-type diffuse large B cell lymphoma patient-derived xenograft (PDX) mouse models[2]. |
Synonyms | CA-4948 |
Molecular Weight | 417.42 |
Formula | C21H19N7O3 |
CAS No. | 1801343-74-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13.89 mg/mL (33.28 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IRAK4-IN-7 1801343-74-7 Immunology/Inflammation NF-Κb IRAK ABC-type large B cell lymphoma IRAK4 CA4948 CA 4948 lymphoma DLBCL IRAK4 IN 7 IL-1R associated kinase non-Hodgkin diffuse IRAK-4-IN-7 Interleukin-1 receptor associated kinase Inhibitor CA-4948 IRAK4IN7 inhibit inhibitor