Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 37.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 459.00 | |
100 mg | In stock | $ 657.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 107.00 |
Description | IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. |
Targets&IC50 | Porcn:80 pM (EC50, in L-Wnt-STF cells) |
In vitro | IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM. |
Molecular Weight | 432.48 |
Formula | C26H20N6O |
CAS No. | 2074607-48-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
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IWP-O1 2074607-48-8 Cytoskeletal Signaling Stem Cells Porcupine Wnt/beta-catenin Wnt IWP-O-1 IWPO1 inhibit Inhibitor IWP O1 inhibitor