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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $37 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $172 | In Stock | |
25 mg | $276 | In Stock | |
50 mg | $396 | In Stock | |
100 mg | $562 | In Stock | |
1 mL x 10 mM (in DMSO) | $107 | In Stock |
Description | IWP-O1, a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. |
In vitro | IWP-O1functions by preventing the secretion of Wnt proteins. IWP-O1 effectively suppressed the phosphorylation of Dvl2/3 in HeLa cells. At the same time, the phosphorylation of low-density lipoprotein receptor-related protein 6 (LRP6). IWP-O1 suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM. |
Molecular Weight | 432.48 |
Formula | C26H20N6O |
Cas No. | 2074607-48-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (138.73 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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