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Ivosidenib

Catalog No. T3617   CAS 1448347-49-6
Synonyms: AG-120

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ivosidenib Chemical Structure
Ivosidenib, CAS 1448347-49-6
Pack Size Availability Price/USD Quantity
2 mg In stock $ 42.00
5 mg In stock $ 66.00
10 mg In stock $ 123.00
25 mg In stock $ 196.00
50 mg In stock $ 315.00
100 mg In stock $ 509.00
1 mL * 10 mM (in DMSO) In stock $ 103.00
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Purity: 100%
Purity: 99.7%
Purity: 99.484%
Purity: 99.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Targets&IC50 IDH1 (R132H):12 nM
In vitro TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1].
Cell Research TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)
Synonyms AG-120
Molecular Weight 582.96
Formula C28H22ClF3N6O3
CAS No. 1448347-49-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 100 mg/mL (171.54 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (85.77 mM)

TargetMolReferences and Literature

1. Erica Hansen, et al. Blood. 2104, 124:3734.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Drug-induced Liver Injury (DILI) Compound Library Inhibitor Library Pediatric Drug Library NO PAINS Compound Library ReFRAME Related Library

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Keywords

Ivosidenib 1448347-49-6 Metabolism Dehydrogenase Isocitrate Dehydrogenase (IDH) inhibit AG 120 Inhibitor AG120 AG-120 inhibitor

 

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