Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 66.00 | |
10 mg | In stock | $ 123.00 | |
25 mg | In stock | $ 196.00 | |
50 mg | In stock | $ 315.00 | |
100 mg | In stock | $ 509.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 103.00 |
Description | Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. |
Targets&IC50 | IDH1 (R132H):12 nM |
In vitro | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1]. |
Cell Research | TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference) |
Synonyms | AG-120 |
Molecular Weight | 582.96 |
Formula | C28H22ClF3N6O3 |
CAS No. | 1448347-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 100 mg/mL (171.54 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (85.77 mM)
You can also refer to dose conversion for different animals. More
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Ivosidenib 1448347-49-6 Metabolism Dehydrogenase Isocitrate Dehydrogenase (IDH) inhibit AG 120 Inhibitor AG120 AG-120 inhibitor