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Jolkinolide B

Catalog No. T2S1040 CAS 37905-08-1

Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.

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Jolkinolide B, CAS 37905-08-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 251.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 626.00
50 mg	In stock	$ 888.00
1 mL * 10 mM (in DMSO)	In stock	$ 251.00

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Description	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.
In vitro	Jolkinolide B has potent anti-inflammatory, and antitumor activities. Jolkinolide B is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) without cytotoxicity. Furthermore, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K (CtsK), and calcitonin receptor (CTR), was significantly inhibited. Jolkinolide Binhibited RANKL-induced activation of NF-ÎºB by suppressing RANKL-mediated IÎºBα degradation. Moreover, Jolkinolide B inhibited RANKL-induced phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK)[1].
Source	Natural Products > Thymelaeaceae > Stellera

Molecular Weight	330.42
Formula	C20H26O4
CAS No.	37905-08-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.3 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Ma X, et al. Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-κB and MAPK signaling pathways. Biochem Biophys Res Commun. 2014 Mar 7;445(2):282-8. 2. Wang, J., Zhou, Y., Bai, X. et al. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells 32, 451–457 (2011).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Antidepressant Compound Library Transcription Factor-Targeted Compound Library Natural Product Library Traditional Chinese Medicine Monomer Library Antioxidant Compound Library Anti-Liver Cancer Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library NF-κB Signaling Compound Library

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Keywords

Jolkinolide B 37905-08-1 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation JAK/STAT signaling MAPK NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells p38 MAPK TNF NF-κB ERK BCL IL Receptor Caspase Akt PI3K JAK STAT JNK mTOR cancer inhibit human U937 Inhibitor leukemic cells inhibitor

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