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L-NMMA acetate

Catalog No. T15697 CAS 53308-83-1

Synonyms: Tilarginine acetate, Methylarginine acetate

L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.

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L-NMMA acetate, CAS 53308-83-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 76.00
10 mg	In stock	$ 109.00
25 mg	In stock	$ 183.00
50 mg	In stock	$ 272.00
100 mg	In stock	$ 397.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.
Targets&IC50	nNOS:0.18 μM(Ki,rat), iNOS:6 μM(Ki,mouse), eNOS:0.4 μM(Ki,human)
In vitro	L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction.

Synonyms	Tilarginine acetate, Methylarginine acetate
Molecular Weight	248.28
Formula	C9H20N4O4
CAS No.	53308-83-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (201.39 mM)

References and Literature

1. Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103(4):1970-2. 2. Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261(1 Pt 2):H46-52. 3. Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max ReFRAME Related Library

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Keywords

L-NMMA acetate 53308-83-1 Immunology/Inflammation NOS Tilarginine Acetate Tilarginine acetate Tilarginine Methylarginine L-NMMA Methylarginine acetate Nitric oxide synthases L NMMA acetate inhibit LNMMA acetate L-NMMA Acetate NO Synthase Inhibitor Methylarginine Acetate inhibitor

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