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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $76 | In Stock | |
10 mg | $109 | In Stock | |
25 mg | $183 | In Stock | |
50 mg | $272 | In Stock | |
100 mg | $397 | In Stock |
Description | L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively. |
Targets&IC50 | nNOS:0.18 μM(Ki,rat), iNOS:6 μM(Ki,mouse), eNOS:0.4 μM(Ki,human) |
In vitro | L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction. |
Alias | Tilarginine acetate, Methylarginine acetate |
Molecular Weight | 248.28 |
Formula | C9H20N4O4 |
Cas No. | 53308-83-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (201.39 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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