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Levetiracetam

Catalog No. T0192   CAS 102767-28-2
Synonyms: UCB L059, SIB-S1

Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.

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Levetiracetam Chemical Structure
Levetiracetam, CAS 102767-28-2
Pack Size Availability Price/USD Quantity
25 mg In stock $ 50.00
50 mg In stock $ 58.00
100 mg In stock $ 98.00
200 mg In stock $ 133.00
500 mg In stock $ 256.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.81%
Purity: 98.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
Kinase Assay EDTA plasma (20 μL) is diluted with 30 μL of DPP-4 assay buffer (100 mM Tris and 100 mM NaCl, adjusted to pH 7.8 with HCl) and mixed with 50 μL of H-Ala-Pro-7-amido-4-trifluoromethylcoumarin. The 200 mM stock solution in dimethylformamide is diluted 1:1000 with water to yield a final concentration of 100 μM. The plate is incubated at room temperature for 10 min, and fluorescence in the wells is determined by using a Victor 1420 Multilabel Counter at an excitation wavelength of 405 nm and an emission wavelength of 535 nm. For the detection of DPP-4 activity in wound lysates, 100 μg of protein from the respective wound lysates are used instead of 20 μL of plasma. Active GLP-1 is also detected from 100 μg of respective wound tissue samples and analyzed by using the Mouse/Rat Total Active GLP-1 Assay Kit.
Synonyms UCB L059, SIB-S1
Molecular Weight 170.21
Formula C8H14N2O2
CAS No. 102767-28-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 17 mg/mL (100 mM)

H2O: 17 mg/mL (100 mM)

TargetMolReferences and Literature

1. Gigant B, et al. Nature, 2005, 435(7041), 519-522. 2. Lukyanetz EA, et al. Epilepsia, 2002, 43(1), 9-18. 3. Rigo JM, et al. Br J Pharmacol, 2002, 136(5), 659-672. 4. Löscher W, et al. J Pharmacol Exp Ther, 1998, 284(2), 474-479. 5. Gower AJ, et al. Epilepsy Res, 1995, 22(3), 207-213.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Metabolism Compound Library FDA-Approved & Pharmacopeia Drug Library Ion Channel Inhibitor Library Methylation Compound Library Bioactive Compound Library Drug-induced Liver Injury (DILI) Compound Library

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Keywords

Levetiracetam 102767-28-2 Chromatin/Epigenetic Membrane transporter/Ion channel Metabolism Others Calcium Channel DNA Methyltransferase DNMTs chemosensitizer vesicle inhibit antiepileptic Temozolomide HDA Inhibitor SV2A UCB L-059 synaptic protein DNA MTases MGMT UCB L059 UCB L 059 SIB-S1 glioblastoma apoptosis inhibitor

 

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