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Lomerizine dihydrochloride
🥰Excellent
Catalog No. T6571Cas No. 101477-54-7
Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796
Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
Lomerizine dihydrochloride
🥰Excellent
Purity: 99.87%
Catalog No. T6571Alias Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796Cas No. 101477-54-7
Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $40 | In Stock | |
| 50 mg | $55 | In Stock | |
| 100 mg | $80 | In Stock | |
| 200 mg | $117 | In Stock | |
| 500 mg | $193 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine. |
| In vitro | Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons. |
| In vivo | Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons. |
| Alias | Terranas, Lomerizine hydrochloride, Lomerizine 2HCl, KB-2796 |
| Molecular Weight | 541.46 |
| Formula | C27H30F2N2O3·2HCl |
| Cas No. | 101477-54-7 |
| Smiles | Cl.Cl.COc1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(OC)c1OC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (27.7 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 49 mg/mL (90.5 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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