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MKC-1

Catalog No. T9831Cas No. 125313-92-0
Alias Ro-31-7453

MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.

MKC-1

MKC-1

Purity: 99.46%
Catalog No. T9831Alias Ro-31-7453Cas No. 125313-92-0
MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
5 mg$127In Stock
10 mg$187In Stock
25 mg$325In Stock
50 mg$469In Stock
100 mg$654In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$141In Stock
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Purity:99.46%
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Product Introduction

Bioactivity
Description
MKC-1 (Ro-31-7453) is an orally bioavailable small-molecule bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking mitotic spindle formation, which may result in apoptosis and tumor cell death.
AliasRo-31-7453
Chemical Properties
Molecular Weight400.39
FormulaC22H16N4O4
Cas No.125313-92-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (137.36 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4976 mL12.4878 mL24.9756 mL124.8782 mL
5 mM0.4995 mL2.4976 mL4.9951 mL24.9756 mL
10 mM0.2498 mL1.2488 mL2.4976 mL12.4878 mL
20 mM0.1249 mL0.6244 mL1.2488 mL6.2439 mL
50 mM0.0500 mL0.2498 mL0.4995 mL2.4976 mL
100 mM0.0250 mL0.1249 mL0.2498 mL1.2488 mL

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