Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
2 mg | In stock | $ 81.00 | |
5 mg | In stock | $ 133.00 | |
10 mg | In stock | $ 226.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 677.00 | |
100 mg | In stock | $ 963.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 145.00 |
Description | MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. |
Targets&IC50 | Plasmodium PI4K inhibitor:(Kdapp) 0.3 μM |
In vitro | MMV390048 against the intraerythrocytic life cycle stages of P. falciparum displayed a steep inhibition curve (IC50: IC90 values of 28 and 40 nM, respectively). |
Molecular Weight | 393.38 |
Formula | C18H14F3N3O2S |
CAS No. | 1314883-11-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (228.79 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MMV390048 1314883-11-8 Microbiology/Virology PI3K/Akt/mTOR signaling PI4K Parasite inhibit MMV-390048 PI4 kinases Inhibitor Phosphatidylinositol 4 kinases MMV 390048 inhibitor