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N-tert-butyl-α-Phenylnitrone

Catalog No. T23046 CAS 3376-24-7

Synonyms: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier.

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N-tert-butyl-α-Phenylnitrone Chemical Structure

N-tert-butyl-α-Phenylnitrone, CAS 3376-24-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 35.00
50 mg	In stock	$ 48.00
100 mg	In stock	$ 72.00
200 mg	In stock	$ 113.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.69%

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Description	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier.
In vitro	Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation[1].
In vivo	In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations[2].

Synonyms	(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide
Molecular Weight	177.24
Formula	C11H15NO
CAS No.	3376-24-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/Ml(282.10 mM)

References and Literature

1. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10. 2. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Fibrosis Compound Library Mitochondria-Targeted Compound Library Pyroptosis Compound Library Antioxidant Compound Library Cuproptosis Compound Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Aging Compound Library

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Keywords

N-tert-butyl-α-Phenylnitrone 3376-24-7 Immunology/Inflammation Neuroscience COX ROS neuroprotective adducts inhibit Cyclooxygenase ERK Inhibitor Scavenger (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide spin BBB N tert butyl α Phenylnitrone N-benzylidene-2-Methylpropan-2-aMine Oxide iNOS N-tert-butyl-alpha-Phenylnitrone nitroxide antioxidant N-tert-butyl-a-Phenylnitrone Reactive Oxygen Species MAPK NtertbutylαPhenylnitrone inhibitor

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