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NNK

Catalog No. T20533 CAS 64091-91-4

Synonyms: Nicotine-derived nitrosamine ketone

NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

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NNK, CAS 64091-91-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 162.00
50 mg	In stock	$ 239.00
100 mg	In stock	$ 289.00
200 mg	In stock	$ 428.00
500 mg	In stock	$ 686.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 100%

Purity: 99.86%

Purity: 99.83%

Purity: 98.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

NNK (Nicotine-derived nitrosamine ketone) is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.

Synonyms	Nicotine-derived nitrosamine ketone
Molecular Weight	207.23
Formula	C10H13N3O2
CAS No.	64091-91-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (965.11 mM), Sonification is recommended.

References and Literature

1. Cheng G, Li J, Zheng M, Zhao Y, Zhou J, Li W. NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor. Int J Environ Res Public Health. 2014 Dec 23;12(1):64-82. 2. Tong M, Yu R, Deochand C, de la Monte SM. Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain. Alcohol Alcohol. 2015 Nov;50(6):670-9. 3. Wu Q, Nadesalingam J, Moodley S, Bai X, Liu M. XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells. Oncotarget. 2015 Jul 20;6(20):18050-65. 4. Tong M, Yu R, Silbermann E, Zabala V, Deochand C, de la Monte SM. Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain. Alcohol Alcohol. 2015 Nov;50(6):680-9. doi: 10.1093/alcalc/agv102. Epub 2015 Sep 15. PubMed PMID: 26373813; PubMed Central PMCID: PMC4608624.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Metabolism Compound Library Bioactive Compound Library Human Endogenous Metabolite Compound Library Plus Anti-Cancer Compound Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Human Metabolite Library

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Related compounds with same targets

Abietic Acid A-69412 PXS-6302 hydrochloride (+/-)-Sigmoidin A 2-TEDC Linetastine CJ-13,610 Lycopodine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NNK 64091-91-4 Metabolism Lipoxygenase Bcl2 inhibit Inhibitor Nicotine-nitrosated derivative Lung cancer c-Myc Phosphorylation Cell proliferation Nicotine-derived nitrosamine ketone Endogenous Metabolite inhibitor

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