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ZMC1
🥰Excellent
Catalog No. T2464Cas No. 71555-25-4
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
ZMC1
🥰Excellent
Purity: 98.97%
Catalog No. T2464Cas No. 71555-25-4
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $32 | In Stock | |
| 5 mg | $52 | In Stock | |
| 10 mg | $85 | In Stock | |
| 25 mg | $159 | In Stock | |
| 50 mg | $288 | In Stock | |
| 100 mg | $490 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $57 | In Stock |
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM). |
| Targets&IC50 | p53 (R175):8 nM |
| In vitro | In cells with mutant p53, NSC319726 (IC50=8 nM) causes a WT-like conformational change in the mutant protein that repairs sequence-specific p53 transcription. |
| In vivo | In cells with mutant p53, NSC319726 (IC50=8 nM) causes a WT-like conformational change in the mutant protein that repairs sequence-specific p53 transcription. |
| Kinase Assay | MTS: 5,000 cells of TOV112D cells (5,000 cells/well, in 100 ml culture) are cultured in 96-well plate to reach the 50%–60% confluence on the second day when treated with serial dilutions of the compounds. The growth is measured by MTS reagent and Victor Plate reader instrument after incubation for 3 days. |
| Cell Research | Viability assays are done. The cells (5×104 cells/well, in 1 ml culture) are cultured in a 12-well plate to reach the 50%–60% confluence on the second day when treated with serial dilutions of the compound. The growth is measured by Guava ViaCount reagent and Guava PCA instrument after incubation for 3 days.(Only for Reference) |
| Molecular Weight | 234.32 |
| Formula | C11H14N4S |
| Cas No. | 71555-25-4 |
| Smiles | C\C(=N/NC(=S)N1CCC1)c1ccccn1 |
| Relative Density. | 1.26g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2.3 mg/mL (10 mM)), Heating is recommended. DMSO: 23.4 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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