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ONC212

Catalog No. T7398 CAS 1807861-48-8

ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.

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ONC212, CAS 1807861-48-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 162.00
25 mg	In stock	$ 275.00
50 mg	In stock	$ 441.00
100 mg	In stock	$ 649.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98%

Biological Description

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Description	ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.
In vitro	In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1].
In vivo	ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2].

Molecular Weight	440.46
Formula	C24H23F3N4O
CAS No.	1807861-48-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (113.52 mM)

References and Literature

1. Nii T, Prabhu VV, Ruvolo V,et al.Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia[J].Leukemia. 2019 Dec;33(12):2805-2816. 2. Lev A , Lulla A R , Wagner J , et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.[J]. Oncotarget, 2017, 8(47):81776-81793.

Citations

1. Wei B, Zhang T, Wang P, et al. Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nature Communications. 2022, 13(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library GPCR Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Apoptosis Compound Library NO PAINS Compound Library Bioactive Compound Library Endoplasmic Reticulum Stress Compound Library Endocrinology-Hormone Compound Library Anti-Cancer Compound Library

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Keywords

ONC212 1807861-48-8 Apoptosis Endocrinology/Hormones GPCR/G Protein GPR Inhibitor inhibit ONC 212 ONC-212 inhibitor

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