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Oxfendazole

Catalog No. T0714 CAS 53716-50-0

Synonyms: RS-8858

Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

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Oxfendazole, CAS 53716-50-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 39.00
100 mg	In stock	$ 57.00
500 mg	In stock	$ 77.00
1 g	In stock	$ 109.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.99%

Purity: 98.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.

In vivo

Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. [1] Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. [2] Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. [3] Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. [4] Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and their respective metabolites in dogs. [5]

Synonyms	RS-8858
Molecular Weight	315.35
Formula	C15H13N3O3S
CAS No.	53716-50-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10 mg/mL (31.71 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Dewa Y, et al. Arch Toxicol,2009, 83(5), 503-511. 2. Gleizes C, et al. Biochem Pharmacol,1991, 41(12), 1813-1820. 3. El-Makawy A, et al. Reprod Nutr Dev,2006, 46(2), 139-156. 4. Dewa Y, et al. Arch Toxicol,2011, 85(2), 155-162. 5. Gokbulut C, et al. Vet Parasitol,2007, 148(3-4), 279-287.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Parasitic Compound Library Drug Repurposing Compound Library Microtubule-Targeted Compound Library Anti-Cancer Metabolism Compound Library Anti-Infection Compound Library Human Metabolite Library Cytoskeletal Signaling Pathway Compound Library Anti-Metabolism Disease Compound Library Target-Focused Phenotypic Screening Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oxfendazole 53716-50-0 Cytoskeletal Signaling Metabolism Microbiology/Virology Glucokinase Microtubule Associated Parasite RS 8858 Inhibitor inhibit RS8858 RS-8858 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.