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Oxiconazole nitrate

Catalog No. T1290 CAS 64211-46-7

Synonyms: Ro 13-8996

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.

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Oxiconazole nitrate, CAS 64211-46-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 103.00
50 mg	In stock	$ 182.00
100 mg	In stock	$ 359.00
200 mg	In stock	$ 498.00
500 mg	In stock	$ 812.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.73%

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Storage & Solubility Information

Description	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.
Targets&IC50	T. tonsurans:0.25 μg/mL (MIC90), T. rubrum:0.5 μg/mL (MIC90)
In vivo	Fusidin(Fusidate Sodium) ameliorates EAM, at least partly, through an inhibitory action on the secretion of TNF-a[1]. It markedly attenuates clinical and histological signs of immunoinflammatory diabetes mellitus in mice given streptozotocin(SZ). The effect is dose-dependent, observed in three different strains of mice. Thus, fusidin might have an antidiabetogenic effect[2].

Synonyms	Ro 13-8996
Molecular Weight	492.14
Formula	C18H13Cl4N3O·HNO3
CAS No.	64211-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (101.6 mM)

References and Literature

1. Carrillo-Munoz AJ, et al. Rev Esp Quimioter. 2006 Jun;19(2):130-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Immunology/Inflammation Compound Library ReFRAME Related Library Clinical Compound Library Anti-Infection Compound Library

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Oxacillin sodium monohydrate Tacrolimus Clopidol Danofloxacin Azidamfenicol Miconazole Sanguinarine citrate Silver sulfadiazine

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Keywords

Oxiconazole nitrate 64211-46-7 Microbiology/Virology Others Antibiotic Antifection Antifungal HCT116 Fungal CYPs Cytochrome P450 PRDX2 CYP3A4 Inhibitor Oxiconazole Nitrate BALB/c nude mice Oxiconazole inhibit colorectal cancer Ro 13-8996 Rifampicin inhibitor

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