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Home > Microbiology&virology > HCV Protease > Penciclovir

Penciclovir

Catalog No. T1643    CAS 39809-25-1    Synonyms: VSA 671, BRL 39123

Penciclovir is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

Pack Size Availability Price/USD Quantity
25 mg In stock 50.00
50 mg In stock 60.00
100 mg In stock 80.00
200 mg In stock 157.00
1 mL * 10 mM (in DMSO) In stock 50.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

Penciclovir is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

Receptor:

EBV; HCMV; HSV-1; HSV-2; VZV;

Chemical Information:
Molecular Weight 253.26
Formula C10H15N5O3
CAS Number 39809-25-1
Solubility

DMSO: 32 mg/mL (126.4 mM)

Water: 1 mg/mL (3.94 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.