Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 90.00 | |
10 mg | In stock | $ 132.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 360.00 | |
100 mg | In stock | $ 540.00 |
Description | Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It possesses a novel chemical structure that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and very little sedative, amnestic or anticonvulsant effects, and so is classified as a nonbenzodiazepine anxiolytic. |
In vitro | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
In vivo | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
Animal Research | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
Synonyms | PK-8165 hydrochloride |
Molecular Weight | 352.9 |
Formula | C22H25ClN2 |
CAS No. | 80221-58-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: >30 mg/mL (94.8 mM)
You can also refer to dose conversion for different animals. More
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Pipequaline hydrochloride 80221-58-5 Membrane transporter/Ion channel Neuroscience GABA Receptor inhibit Gamma-aminobutyric acid Receptor Pipequaline Hydrochloride PK-8165 hydrochloride PK-8165 PK8165 Pipequaline PK 8165 PK 8165 Hydrochloride Inhibitor PK8165 Hydrochloride γ-Aminobutyric acid Receptor PK-8165 Hydrochloride inhibitor