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Piperlongumine

Catalog No. T6947   CAS 20069-09-4
Synonyms: PPLGM, Piplartine

Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).

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Piperlongumine Chemical Structure
Piperlongumine, CAS 20069-09-4
Pack Size Availability Price/USD Quantity
10 mg In stock $ 30.00
25 mg In stock $ 50.00
50 mg In stock $ 80.00
100 mg In stock $ 122.00
1 mL * 10 mM (in DMSO) In stock $ 30.00
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Purity: 99.89%
Purity: 98.09%
Purity: 97.21%
Purity: 97.03%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
In vitro Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture[1] As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. [2] Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. [3]
In vivo Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters. [4]
Kinase Assay MEK Kinase Assay: Kinase inactive murine ERK2 (mERK2) K52A/T183A is affinity purified from Escherichia coli expressed using the pET21a vector. MEK1 kinase activity is determined using mERK2 K52A T183A as the substrate. Recombinant MEK1 enzyme (5 nM) is first activated by 0.02 unit or 1.5 nM of RAF1 in the presence of 25 mM HEPES (pH 7.8), 1 mM MgCl2, 50 mM NaCl, 0.2 mM EDTA, and 50 μM ATP for 30 minutes at 25 °C. The reactions are initiated by adding 2 μM of mERK2K52A T183A and 2.5 μCi [γ-33P] ATP in a total volume of 20 μL. The MEK2 kinase activity is determined similarly except that activation by RAF1 is not needed and 11 nM of MEK2 enzyme (active) are used in the assays.Kinase profiling is performed by Invitrogen using their Select Screen Kinase Profiling Service. The Z'-LYTE biochemical assay is used. RDEA119 is assayed in quadruplicate at 10 μM against 205 kinases.
Cell Research MCF-7 and 786-O cells are incubated with various PL concentrations for 48h. Cell proliferation is analysed by CellTiter Blue assay. Effective doses (ED) are calculated using XLift, Microsoft Excel add-in. (Only for Reference)
Source
Synonyms PPLGM, Piplartine
Molecular Weight 317.34
Formula C17H19NO5
CAS No. 20069-09-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.7 mg/mL (100 mM)

TargetMolReferences and Literature

1. Dhillon H, et al. Toxicol Rep. 2014, 1:309-318. 2. Iwashita M, et al. Eur J Pharmacol. 2007, 570(1-3), 38-42. 3. Ryu J, et al. Nat Prod Res. 2014, 28(22), 2040-2043. 4. Bezerra DP, et al. J Appl Toxicol. 2008, 28(5), 599-607. 5. Zou P, et al. Cancer Lett. 2016, 375(1):114-26. 6. Wu X, e,t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119(12):10358-10364

TargetMolCitations

1. Qiu C, Shen X, Lu H, et al.Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.Cell Death Discovery.2023, 9(1): 375. 2. Kong Y, Liu Y, Li X, et al.Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis.Journal of Translational Medicine.2023, 21(1): 1-19. 3. Ibrahim F A R, Hussein N A, Soliman A Y M, et al.Chitosan-loaded piperlongumine nanoparticles and kaempferol enhance the anti-cancer action of doxorubicin in targeting of Ehrlich solid adenocarcinoma: in vivo and in silico modeling study.Medical Oncology.2024, 41(2): 1-17.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Liver Cancer Compound Library Natural Product Library Covalent Natural Product Library Chinese Pharmacopoeia Natural Product Library Anti-Obesity Compound Library Selected Plant-Sourced Compound Library Alkaloid Natural Product Library Traditional Mongolian Medicine Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Piperlongumine 20069-09-4 Apoptosis Autophagy Immunology/Inflammation MAPK Metabolism Microbiology/Virology NF-Κb Antibacterial Reactive Oxygen Species Ferroptosis ERK ROS Extracellular signal regulated kinases Bacterial Inhibitor inhibit PPLGM Piplartine inhibitor

 

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