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Ponicidin

Catalog No. T2S1975 CAS 52617-37-5

Synonyms: Rubescensine B

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.

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Ponicidin, CAS 52617-37-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 219.00
25 mg	In stock	Inquiry
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 117.00

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Purity: 99.92%

Purity: 99.20%

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Chemical Properties

Storage & Solubility Information

Description	Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.
In vitro	K562 cells in culture medium in vitro were given different concentrations of Ponicidin (10-50 micromol x L(-1)) for 24, 48, and 72 h. The inhibitory rate of the cells was measured by MTT assay, cell apoptotic rates were detected by flow cytometry (FCM) using Annexin V staining after K562 cells were treated with different concentrations of Ponicidin for 72 hours, and cell morphology was observed by Wright-Giemsa staining. Ponicidin (over 30 micromol x L(-1)) could inhibit the growth of K562 cells in both time- and dose-dependent manner. FCM analysis revealed that apoptotic cells were gradually increased in a dose-dependent manner after treatment for 72 hours, and that marked morphological changes of cell apoptosis such as condensation of chromatin was clearly observed by Wright-Giemsa staining after treatment by 50 micromol x L(-1) Ponicidin. Furthermore, Western blotting also showed that expression of p-AKT and p-P85 in PI3K/AKT signaling pathways was downregulated dramatically whereas the expression of p-P38, as well as p-ERK and p-JNK, remained unchanged after the cells were treated by PON for 48 h.
Source	Natural Products > Lamiaceae > Isodon

Synonyms	Rubescensine B
Molecular Weight	362.42
Formula	C20H26O6
CAS No.	52617-37-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (689.81 mM), Sonication is recommended.

References and Literature

1. Xiaodan Liu, et al. Apoptosis inducing effect of ponicidin in leukemia K562 cells and its mechanisms of action. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2161-5. 2. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. Int J Mol Sci. 2008 Nov;9(11):2265-77.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library Natural Product Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Bioactive Compound Library Anti-Lung Cancer Compound Library Anti-Tumor Natural Product Library

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Keywords

Ponicidin 52617-37-5 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT inhibit Inhibitor Rubescensine B inhibitor

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