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RS 67333 hydrochloride

🥰Excellent
Catalog No. T23265Cas No. 168986-60-5
Alias RS 67333 HCl, RS 67333 (hydrochloride)

RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.

RS 67333 hydrochloride

RS 67333 hydrochloride

🥰Excellent
Purity: 98.78%
Catalog No. T23265Alias RS 67333 HCl, RS 67333 (hydrochloride)Cas No. 168986-60-5
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
Pack SizePriceAvailabilityQuantity
10 mg$43In Stock
25 mg$103In Stock
50 mg$170In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Purity:98.78%
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Product Introduction

Bioactivity
Description
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
In vitro
RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT [1].
AliasRS 67333 HCl, RS 67333 (hydrochloride)
Chemical Properties
Molecular Weight389.36
FormulaC19H30Cl2N2O2
Cas No.168986-60-5
SmilesCl.O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 9 mg/mL (23.1 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.5683 mL12.8416 mL25.6832 mL128.4159 mL
5 mM0.5137 mL2.5683 mL5.1366 mL25.6832 mL
10 mM0.2568 mL1.2842 mL2.5683 mL12.8416 mL
20 mM0.1284 mL0.6421 mL1.2842 mL6.4208 mL

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