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Rifabutin

Catalog No. T1501 CAS 72559-06-9

Synonyms: inhibit, LM-427, Antibiotic, LM 427, Rifabutin, Ansamycin, Inhibitor, Bacterial, LM427

Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

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Rifabutin, CAS 72559-06-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	inhibit, LM-427, Antibiotic, LM 427, Rifabutin, Ansamycin, Inhibitor, Bacterial, LM427
Molecular Weight	847.019
Formula	C46H62N4O11
CAS No.	72559-06-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 38 mg/mL (44.9 mM)

DMSO: 56 mg/mL (66.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kunin CM, et al. Clin Infect Dis, 1996, 22 Suppl 1, S3-13. 2. Oesch F, et al. J Antimicrob Chemother, 1996, 37(6), 1111-1119. 3. Katoh M, et al. Xenobiotica, 2005, 35(9), 863-875. 4. Araujo FG, et al. Antimicrob Agents Chemother, 1994, 38(3), 570-575.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library HIF-1 Signaling Pathway Compound Library Antibiotics Library Inhibitor Library Macrocyclic Compound Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Salinomycin sodium salt Ramoplanin Ceftazidime Pentahydrate Amikacin hydrate Telithromycin Taniborbactam hydrochloride Sulfaethoxypyridazine KDOAM-25

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.