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Rose Bengal sodium

Catalog No. T7651 CAS 632-69-9

Synonyms: Rose Bengal

Rose Bengal sodium is a potent inhibitor of VGlut and vesicular monoamine transporter (VMAT) (Ki of 19 and 64 nM for VGlut andVMAT, respectively）

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Rose Bengal sodium, CAS 632-69-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 39.00
100 mg	In stock	$ 64.00
200 mg	In stock	$ 93.00
500 mg	In stock	$ 153.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 91.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rose Bengal sodium is a potent inhibitor of VGlut and vesicular monoamine transporter (VMAT) (Ki of 19 and 64 nM for VGlut andVMAT, respectively）
In vitro	Rose Bengal immobilized onto silicon showed good antibacterial activity in the dark under ultrasonic activation[1]
Cell Research	Bacteria were grown to a concentration of 10^8 CFU/mL and then diluted with sterile saline by serial decimal dilutions to concentrations of 10^3–10^7 CFU/mL.?Three milliliters of bacterial suspensions was transferred into flat-bottom 2.5 cm diameter 20 mL vials.?Before the experiment, samples were taken from each vial to determine the initial bacterial concentration.?Free Rose Bengal at various concentrations or Rose Bengal immobilized onto silicone was added to all vials, except for the controls.?After adding Rose Bengal, all subsequent procedures were performed under dark conditions.?Vials with bacterial suspensions with or without Rose Bengal were held tight to the bottom of an ultrasonic bath in a plastic holder VU03H ?and treated by ultrasound at a frequency of 38 kHz and a field strength of 4.1 W/cm^3 for 1 to 10 min. After the treatment, 100 μL samples were diluted by several decimal dilutions and were spread over BHA plates with a Drigalsky spreader.?The plates were incubated at 37 °C overnight and the bacterial cell concentration was determined taking dilutions into account using the viable count method, where CFU were counted by means of a colony counter Scan 500.?In control experiments, bacterial cultures were tested in the absence of Rose Bengal without sonication, in the absence of Rose Bengal under sonication and in the presence of Rose Bengal without sonication[1].

Synonyms	Rose Bengal
Molecular Weight	1017.64
Formula	C20H2Cl4I4Na2O5
CAS No.	632-69-9

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.17 mg/mL (10 mM)

References and Literature

1. Faina Nakonechny , Margarita Barel , Arad David ,et al.Dark Antibacterial Activity of Rose Bengal[J].Int J Mol Sci, 20 (13) 2019 Jun 29 2. Anju V , Paramanantham P , Sruthil S L , et al. Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli[J]. Photodiagnosis and Photodynamic Therapy, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Approved Drug Library Anti-Infection Compound Library

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Keywords

Rose Bengal sodium 632-69-9 Membrane transporter/Ion channel Microbiology/Virology Influenza Virus Monoamine Transporter Rose Bengal fluorescein Inhibitor dye crimson-coloured ophthalmic antiviral inhibit diagnostic derivative inhibitor

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