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Zapnometinib (ATR-002) is a MEK inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $40 | In Stock | |
10 mg | $60 | In Stock | |
25 mg | $73 | In Stock | |
50 mg | $139 | In Stock | |
100 mg | $272 | In Stock | |
200 mg | $396 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | Zapnometinib (ATR-002) is a MEK inhibitor. |
Targets&IC50 | MEK:5.7 nM |
In vitro | Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1]. |
In vivo | Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1]. |
Alias | PD0184264, ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid |
Molecular Weight | 409.55 |
Formula | C13H7ClF2INO2 |
Cas No. | 303175-44-2 |
Smiles | OC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl |
Relative Density. | 1.946 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (146.50 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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