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Sabizabulin

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Purity:99.76%

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COA HNMR LCMS HPLC

Sabizabulin

Catalog No. T17228Cas No. 1332881-26-1

Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7. Sabizabulin shows antiproliferative activity and can be used in prostate cancer studies.

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Pack Size	Price	Availability
1 mg	$148	In Stock
2 mg	$218	In Stock
5 mg	$372	In Stock
10 mg	$576	In Stock
25 mg	$927	In Stock
50 mg	$1,260	In Stock
100 mg	$1,680	In Stock
500 mg	$3,390	In Stock

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Product Introduction

Bioactivity

Description	Sabizabulin (ABI-231) is an effective and orally bioavailable inhibitor of α and β tubulin against panels of melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7. Sabizabulin shows antiproliferative activity and can be used in prostate cancer studies.
In vitro	Sabizabulin (2.5-80 nM) inhibits Panc-1, AsPC-1 and HPAF-II cells growth in a dose and time-dependent manner with IC50s of 25, 35 and 35 nM for 24 hours and 11.8, 15.5, and 25 nM for 48 hours. Sabizabulin (5-20 nM) inhibits pro-Caspase 3 and 9 and activates Caspase-3 and 9 in a dose-dependent manner. Sabizabulin (5-20 nM) induces the expression of Bax and Bad and inhibits the expression of Bcl-2 and Bcl-xl proteins. Sabizabulin (5-20 nM) dose-dependently arrests Panc-1 and AsPC-1 cells in G2/M phase[4].
In vivo	Sabizabulin (50 μg/mouse; intra-tumorally) potently inhibits tumor growth and shows no apparent toxicity[4].
Alias	ABI-231, VERU-111

Chemical Properties

Molecular Weight	377.39
Formula	C21H19N3O4
Cas No.	1332881-26-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (132.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6498 mL	13.2489 mL	26.4978 mL	132.4889 mL
5 mM	0.5300 mL	2.6498 mL	5.2996 mL	26.4978 mL
10 mM	0.2650 mL	1.3249 mL	2.6498 mL	13.2489 mL
20 mM	0.1325 mL	0.6624 mL	1.3249 mL	6.6244 mL
50 mM	0.0530 mL	0.2650 mL	0.5300 mL	2.6498 mL
100 mM	0.0265 mL	0.1325 mL	0.2650 mL	1.3249 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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