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Solifenacin
Catalog No. T8147Cas No. 242478-37-1
Alias YM905 free base
Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
Solifenacin
Catalog No. T8147Alias YM905 free baseCas No. 242478-37-1
Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $39 | In Stock | |
| 50 mg | $58 | In Stock | |
| 100 mg | $93 | In Stock | |
| 500 mg | $221 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively. |
| Targets&IC50 | M2 mAChR:6.9 (ki), M3 mAChR:8 (ki), M1 receptor:7.6 (ki) |
| In vivo | Solifenacin exerts minimal inhibitory effects on salivary and cardiac responses at a dosage of 630 nmol/kg (0.3 mg/kg), achieving inhibition levels of 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At lower doses (63 and 210 nmol/kg or 0.03 and 0.1 mg/kg), Solifenacin slightly enhances saliva secretion. Conversely, it reduces bladder responses by 40% at 210 nmol/kg (0.1 mg/kg) and completely suppresses them at 2100 nmol/kg (1 mg/kg). Intravenously administered, Solifenacin (0.01 to 0.3 mg/kg) progressively augments bladder capacity and the volume of urine voided when dosed at 0.03 mg/kg or higher, without impacting residual volume or micturition pressure at any administered dosage. |
| Alias | YM905 free base |
| Molecular Weight | 362.46 |
| Formula | C23H26N2O2 |
| Cas No. | 242478-37-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (151.74 mM), Sonication is recommended.  H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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