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Sulfathiazole

Catalog No. T0747   CAS 72-14-0
Synonyms: 2-Sulfanilamidothiazole

Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine.

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Sulfathiazole Chemical Structure
Sulfathiazole, CAS 72-14-0
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Purity: 99.97%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine.
In vitro Sulfathiazole (20 μg/L) starts to be degraded between day 31 and day 38 in one of the two batch reactors containing different wastewater matrices. Sulfathiazole is degraded at a substantially faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole has acidity constant of pKa of 7.1and retention times (tR) of 7.8. S/N values for Sulfathiazole are above 100 at the 1 mg/kg level. [2] Sulfathiazole sorption to inorganic sorbents exhibits pronounced pH dependence consistent with sorbate speciation and sorbent charge properties. Sulfathiazole cations are most important for sorption to clay minerals, followed by neutral species. [3] Sulfathiazole posseses at least five crystalline or polymorphic forms: I, II, III, IV and V. Although both amido and imido forms are possible for the sulfathiazole molecule, the Sulfathiazole exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) causes a significant increase in reactive oxygen species (ROS) generation and lipid peroxidation in the presence of ultraviolet B (UV-B) light. Exposure to Sulfathiazole and UV-B light causes apparent up-regulation of alpha-esterase, hemoglobin, and vitellogenin mRNA and significantly affect the survival of daphnids. [5]
Synonyms 2-Sulfanilamidothiazole
Molecular Weight 255.32
Formula C9H9N3O2S2
CAS No. 72-14-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (188 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Pérez S, et al. Environ Toxicol Chem, 2005, 24(6), 1361-136 2. Haller MY, et al. J Chromatogr A, 2002, 952(1-2), 111-120. 3. Kahle M, et al. Chemosphere, 2007, 68(7), 1224-1231. 4. Bellu S, et al. Quim Nova, 2003, 26(2), 188-192. 5. Kim J, et al. Aquat Toxicol, 2009, 91(1), 87-94.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library NO PAINS Compound Library FDA-Approved Drug Library Human Metabolite Library Anti-Bacterial Compound Library Bioactive Compound Library

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Keywords

Sulfathiazole 72-14-0 Autophagy Microbiology/Virology Antibiotic Antibacterial sulfonamide Bacterial bacteria 2-Sulfanilamidothiazole Inhibitor inhibit inhibitor

 

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