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Tiopronin

Catalog No. T1630 CAS 1953-02-2

Synonyms: Thiopronine, Acadione, Captimer

Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.

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Tiopronin, CAS 1953-02-2

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 39.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.87%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tiopronin (Acadione), a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.
In vitro	Tiopronin is an antioxidant with a free thiol (sulfidryl) group that has been shown to protect against cisplatin nephrotoxicity both in vitro and in vivo. Tiopronin improves the defence of the cochlea and scavenge the reactive oxygen species, whereas vitamin E (a-tocopherol) and vitamin C act by inhibiting lipid peroxidation and preventing free radical formation. [1] Tiopronin (2 mM) completely prevents the Cisplatin-induced increase in enzyme leakage and substantially blocks the decrease of MTT reduction caused by Cisplatin. Tiopronin also significantly protects the renal slices from cisplatin-induced toxic effects. Tiopronin protects against cisplatin-induced nephrotoxicity by acting as an alternative target for Cisplatin both intra- and extracellularly and thus protects against cisplatin-induced depletion of glutathione in the kidney cell. [2] Tiopronin protects rat kidney slices in vitro from the nephrotoxic effects of Cisplatin and does not reduce the antitumour activity of Cisplatin. Tiopronin provides marked protection againstcisplatin-induced increases in urea and creatinine. [3] Tiopronin protects against Cisplatin-induced changes in the adenine nucleotides in rat renal cortical slices. [4]
In vivo	Tiopronin significantly lowers both the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, while only the serum ALT level is lowered by ursodeoxycholic acid (UDCA) in rats. Tiopronin significantly decreases the serum and liver levels of triglyceride (TG), total cholesterol (TC) and free fatty acids (FFA) as well as the serum LDL-C level, and increases the serum HDL-C level. [5]

Synonyms	Thiopronine, Acadione, Captimer
Molecular Weight	163.19
Formula	C5H9NO3S
CAS No.	1953-02-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL (183.8 mM)

H2O: 29 mg/mL (177.7 mM)

DMSO: 30 mg/mL (183.8 mM)

References and Literature

1. Fetoni AR, et al. Acta Otolaryngol,2004, 124(4), 421-426. 2. Zhang JG, et al. Toxicol Appl Pharmacol,1996, 141(2), 425-433. 3. Zhang JG, et al. Hum Exp Toxicol,1999, 18(12), 713-717. 4. Zhang JG, et al. J Pharm Pharmacol,1997, 49(11), 1136-1140. 5. Wang JQ, et al. Acta Pharmacol Sin,2012, 33(6), 791-797.

Citations

1. Huang L, Mao X, Li Y, et al. Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease. Immunity. 2021, 54(8): 1728-1744. e7.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library ReFRAME Related Library Human Metabolite Library Anti-Metabolism Disease Compound Library Nonsteroidal Anti-Inflammatory Compound Library Bioactive Compound Library Oxidation-Reduction Compound Library Anti-Aging Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tiopronin 1953-02-2 Immunology/Inflammation ROS Inhibitor Thiopronine Acadione Captimer inhibit inhibitor

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