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Tofogliflozin (hydrate)

Catalog No. T5016 CAS 1201913-82-7

Synonyms: Tofogliflozin hydrate, CSG-452 hydrate

Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).

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Tofogliflozin (hydrate) Chemical Structure

Tofogliflozin (hydrate), CAS 1201913-82-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 143.00
25 mg	In stock	$ 273.00
50 mg	In stock	$ 492.00
100 mg	In stock	$ 688.00
200 mg	In stock	$ 975.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98.78%

Purity: 97.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).
Targets&IC50	SGLT2 (rat):14.9 nM(Ki) , SGLT2:2.9 nM , SGLT2:6.4 nM(Ki), SGLT2 (human):2.9 nM(Ki)
In vitro	Tofogliflozin, a highly selective inhibitor of SGLT2 on oxidative stress generation, inflammatory and proapoptotic reactions in cultured human proximal tubular cells exposed to high glucose.?Tofogliflozin dose-dependently suppressed glucose entry into tubular cells.?High glucose exposure (30 mM) for 4 and 24 h significantly increased oxidative stress generation in tubular cells, which were suppressed by the treatment of tofogliflozin or an antioxidant N-acetylcysteine (NAC).?Monocyte chemoattractant protein-1 (MCP-1) gene expression and apoptotic cell death were induced by 4 h- and 8 day-exposure to high glucose, respectively, both of which were also blocked by tofogliflozin or NAC.?The present study suggests that SGLT2-mediated glucose entry into tubular cells could stimulate oxidative stress and evoke inflammatory and proapoptotic reactions in this cell type.?Blockade of glucose reabsorption in tubular cells by SGLT2 inhibitor might exert beneficial effects on tubulointerstitial damage in diabetic nephropathy[1].

Synonyms	Tofogliflozin hydrate, CSG-452 hydrate
Molecular Weight	404.45
Formula	C22H28O7
CAS No.	1201913-82-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.33 mg/mL (0.82 mM), Sonification is recommended.

DMSO: 90 mg/mL (222.52 mM)

References and Literature

1. Ishibashi Y, et al. Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation. Horm Metab Res. 2016 Mar;48(3):191-5. 2. Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library GPCR Compound Library Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library Glycometabolism Compound Library Glutamine Metabolism Compound Library

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Keywords

Tofogliflozin (hydrate) 1201913-82-7 GPCR/G Protein Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species ROS SGLT Tofogliflozin Hydrate inhibit CSG 452 Hydrate CSG 452 Inhibitor CSG452 CSG-452 CSG452 Hydrate Tofogliflozin Sodium-dependent glucose cotransporters CSG-452 Hydrate Tofogliflozin hydrate CSG-452 hydrate inhibitor

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