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Trifluridine

Catalog No. T1428 CAS 70-00-8

Synonyms: TFT, Thymidylate Synthase, Nucleoside Antimetabolite/Analog, Herpes simplex virus, inhibit, Trifluridine, NSC 529182, Trifluridina, Inhibitor, HSV, 5-Trifluorothymidine, Trifluorothymidine, Viroptic, Orthopoxvirus, NSC 75520

Trifluridine is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.

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Trifluridine, CAS 70-00-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	TFT, Thymidylate Synthase, Nucleoside Antimetabolite/Analog, Herpes simplex virus, inhibit, Trifluridine, NSC 529182, Trifluridina, Inhibitor, HSV, 5-Trifluorothymidine, Trifluorothymidine, Viroptic, Orthopoxvirus, NSC 75520
Molecular Weight	296.202
Formula	C10H11F3N2O5
CAS No.	70-00-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 14.8 mg/mL (50 mM)

DMSO: 29.6 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Yamashita F, et al. Cancer Chemother Pharmacol,2015 Jun 18. 2. Sakamoto K, et al. Int J Oncol,2015, 46(6), 2327-2334. 3. Germano A, et al. Mol Cell Endocrinol. 2014 Jan 25;382(1):1-7. 4. Rootman DS, et al. Invest Ophthalmol Vis Sci,1989, 30(4), 678-683. 5. Tanaka N, et al. Oncol Rep,2014, 32(6), 2319-2326.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Nucleotide Compound Library DNA Damage & Repair Compound Library Covalent Inhibitor Library Fluorochemical Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library

Related Products

Related compounds with same targets

Shizukaol B Licorisoflavan A Kobophenol A Dehydrodiconiferyl alcohol Capillarisin 1,6,7-Trihydroxyxanthone Dihydroguaiaretic acid Dehydroglyasperin D

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.