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Triparanol

Catalog No. T26296 CAS 78-41-1

Synonyms: MER-29, NSC 65345, NSC-65345, NSC65345

Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.

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Triparanol, CAS 78-41-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 498.00
5 mg	In stock	$ 1,130.00
10 mg	In stock	$ 1,520.00
25 mg	In stock	$ 2,260.00
50 mg	In stock	$ 2,990.00
100 mg	In stock	$ 4,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,210.00

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Purity: 99.73%

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Description	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.
In vitro	Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol[2].

Synonyms	MER-29, NSC 65345, NSC-65345, NSC65345
Molecular Weight	438
Formula	C27H32ClNO2
CAS No.	78-41-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (114.16 mM)

References and Literature

1. Officioso A, et al. Triggering of Erythrocyte Death by Triparanol. Toxins (Basel). 2015 Aug 24;7(8):3359-71. 2. Bi X, et al. Triparanol suppresses human tumor growth in vitro and in vivo [published correction appears in Biochem Biophys Res Commun. 2012 Nov 2;427(4):808]. Biochem Biophys Res Commun. 2012;425(3):613-618. 3. Ramu A, Glaubiger D, Fuks Z. Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues. Cancer Res. 1984 Oct;44(10):4392-5. 4. Mizuno GR, Chapman CJ, Chipault JR, Pfeiffer DR. Lipid composition and (Na+ + K+)-ATPase activity in rat lens during triparanol-induced cataract formation. Biochim Biophys Acta. 1981 Jun 9;644(1):1-12.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Neuronal Differentiation Compound Library Bioactive Compounds Library Max Human Metabolite Library Stem Cell Differentiation Compound Library

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Keywords

Triparanol 78-41-1 Apoptosis GPCR/G Protein Stem Cells Hedgehog/Smoothened PTCH1 Hedgehog MER-29 24-DHCR cholesterol biosynthesis NSC 65345 inhibit MER 29 tumor growth Inhibitor MER29 NSC-65345 NSC65345 inhibitor

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