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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $49 | In Stock | |
5 mg | $119 | In Stock | |
10 mg | $226 | In Stock | |
25 mg | $382 | In Stock | |
50 mg | $533 | In Stock | |
100 mg | $738 | In Stock | |
200 mg | $993 | In Stock | |
1 mL x 10 mM (in DMSO) | $137 | In Stock |
Description | UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. |
In vitro | UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs. |
In vivo | In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284. |
Molecular Weight | 441.56 |
Formula | C26H35NO5 |
Cas No. | 299420-83-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (113.23 mM), Sonication is recommended. DMSO: 25 mg/mL (55.62 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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