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UC-514321

UC-514321
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
Catalog No. T13950Cas No. 299420-83-0
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Purity:97%
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UC-514321

Catalog No. T13950Cas No. 299420-83-0
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$49In Stock
5 mg$119In Stock
10 mg$226In Stock
25 mg$382In Stock
50 mg$533In Stock
100 mg$738In Stock
200 mg$993In Stock
1 mL x 10 mM (in DMSO)$137In Stock
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Product Introduction

Bioactivity
Description
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
In vitro
UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs.
In vivo
In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284.
Chemical Properties
Molecular Weight441.56
FormulaC26H35NO5
Cas No.299420-83-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (113.23 mM), Sonication is recommended.
DMSO: 25 mg/mL (55.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.2647 mL11.3235 mL22.6470 mL113.2349 mL
5 mM0.4529 mL2.2647 mL4.5294 mL22.6470 mL
10 mM0.2265 mL1.1323 mL2.2647 mL11.3235 mL
20 mM0.1132 mL0.5662 mL1.1323 mL5.6617 mL
50 mM0.0453 mL0.2265 mL0.4529 mL2.2647 mL
H2O
1mg5mg10mg50mg
100 mM0.0226 mL0.1132 mL0.2265 mL1.1323 mL

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