Powder: -20°C for 3 years
In solvent: -80°C for 2 years
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
Description | URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). |
Targets&IC50 | MLK2:42nM, DLK:150 nM, MLK1:19nM, MLK3:14nM |
Kinase Assay | HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds. |
Synonyms | URMC099, URMC 099 |
Molecular Weight | 421.548 |
Formula | C27H27N5 |
CAS No. | 1229582-33-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: <1 mg/mL
Ethanol: 6 mg/mL (14.2 mM)
DMSO: 75 mg/mL (177.9 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
URMC-099 1229582-33-5 DNA损伤和修复 MAPK信号通路 表观遗传 代谢 蛋白酪氨酸激酶 干细胞 细胞骨架 细胞周期 血管生成 自噬 Aurora Kinase Autophagy Bcr-Abl CDK c-Met/HGFR DNA Alkylation IGF-1R LRRK2 MEK MLK ROCK SGK Src Syk Trk receptor VEGFR inhibit MLKs URMC 099 URMC099 Inhibitor Mixed Lineage Kinase inhibitor