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URMC-099

Catalog No. T6057 CAS 1229582-33-5

Synonyms: URMC099, URMC 099

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).

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URMC-099, CAS 1229582-33-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
Targets&IC50	MLK2:42nM, DLK:150 nM, MLK1:19nM, MLK3:14nM
Kinase Assay	HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.

Synonyms	URMC099, URMC 099
Molecular Weight	421.548
Formula	C27H27N5
CAS No.	1229582-33-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 6 mg/mL (14.2 mM)

DMSO: 75 mg/mL (177.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Goodfellow VS, et al. J Med Chem. 2013, 56(20), 8032-8048. 2. Marker DF, et al. J Neurosci. 2013, 33(24), 91998-1202010. 3. Polesskaya O, et al. Mol Immunol. 2014, 58(2), 214-222.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Anti-Metabolism Disease Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

URMC-099 1229582-33-5 DNA损伤和修复 MAPK信号通路表观遗传代谢蛋白酪氨酸激酶干细胞细胞骨架细胞周期血管生成自噬 Aurora Kinase Autophagy Bcr-Abl CDK c-Met/HGFR DNA Alkylation IGF-1R LRRK2 MEK MLK ROCK SGK Src Syk Trk receptor VEGFR inhibit MLKs URMC 099 URMC099 Inhibitor Mixed Lineage Kinase inhibitor

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