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URMC-099

Catalog No. T6057   CAS 1229582-33-5
Synonyms: URMC099, URMC 099

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).

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URMC-099, CAS 1229582-33-5
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
Targets&IC50 MLK2:42nM, DLK:150 nM, MLK1:19nM, MLK3:14nM
Kinase Assay HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds.
Synonyms URMC099, URMC 099
Molecular Weight 421.548
Formula C27H27N5
CAS No. 1229582-33-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 6 mg/mL (14.2 mM)

DMSO: 75 mg/mL (177.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Goodfellow VS, et al. J Med Chem. 2013, 56(20), 8032-8048. 2. Marker DF, et al. J Neurosci. 2013, 33(24), 91998-1202010. 3. Polesskaya O, et al. Mol Immunol. 2014, 58(2), 214-222.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets
Tripolin A CCT129202 SCH-1473759 L 888607 Racemate LY3295668 Centrinone-B Barasertib Aurora B inhibitor 1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

URMC-099 1229582-33-5 DNA损伤和修复 MAPK信号通路 表观遗传 代谢 蛋白酪氨酸激酶 干细胞 细胞骨架 细胞周期 血管生成 自噬 Aurora Kinase Autophagy Bcr-Abl CDK c-Met/HGFR DNA Alkylation IGF-1R LRRK2 MEK MLK ROCK SGK Src Syk Trk receptor VEGFR inhibit MLKs URMC 099 URMC099 Inhibitor Mixed Lineage Kinase inhibitor