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Vancomycin

Catalog No. T8641 CAS 1404-90-6

Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting ribonucleic acid synthesis. Vancomycin can be used for the treatment of serious infections for which all antibiotics have failed.

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Vancomycin, CAS 1404-90-6

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Description	Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting ribonucleic acid synthesis. Vancomycin can be used for the treatment of serious infections for which all antibiotics have failed.
In vitro	METHODS: B. burgdorferi was treated with Vancomycin (0.5-2.0 µg/mL) for 24 h and cell morphology was examined using real-time time-lapse microscopy. RESULTS: At higher concentrations of Vancomycin (≥1.0 µg/mL), many abnormal cells were observed, which were visually identified by vesiculation, granule formation, and morphological changes. The proportion of these abnormal bacteria in the population increased in a dose-dependent manner. [1] METHODS: Human osteosarcoma cells MG-63 were treated with Vancomycin (10-10000 µg/mL) for 24-72 h. Cell counts were measured using an Elzone Celi Counter. RESULTS: Localized levels of Vancomycin at 1000 µg/mL and below had little effect on osteoblast replication, and concentrations of 10,000 µg/mL resulted in cell death. [2]
In vivo	METHODS: To detect nephrotoxicity, Vancomycin (400 mg/kg) and Vitamin C (200 mg/kg) were administered intraperitoneally to C57BL/6J mice once daily for seven days. RESULTS: Renal index, renal injury score, apoptosis, serum Cr and BUN, as well as renal Cr, BUN, MDA, IL-1β, IL-6, TNF-α, and NF-κB were higher in the Vancomycin group than in the control group, whereas body weight and renal SOD activity were lower. On the contrary, no differences were observed between the control and Vitamin C groups in all these indices. [3] METHODS: To deplete the intestinal microbiota of mice, the antibiotics (ABX) Vancomycin (0.5 g/L), Ampicillin (1 g/L), Neomycin sulfate (1 g/L), and metronidazole (1 g/L) were administered to mice by drinking water for two weeks. RESULTS: Antibiotics significantly reduced the diversity and composition of the gut microbiota. [4]

Molecular Weight	1449.25
Formula	C66H75Cl2N9O24
CAS No.	1404-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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DMSO: Slightly soluble

References and Literature

1. Harman MW, et al. Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium. Biophys J. 2017 Feb 28;112(4):746-754. 2. Edin ML, et al. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res. 1996 Dec;(333):245-51. 3. He J, et al. Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice. Ann Transl Med. 2021 Aug;9(16):1319. 4. Li F, et al. The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia. Gut Microbes. 2022 Jan-Dec;14(1):2096989.

Citations

1. Shan T, Huang Y, Zhao Z, et al. Ketogenic diet restrains herpes simplex encephalitis via gut microbes. Microbes and Infection. 2022: 105061. 2. Li F, Wang Y, Song X, et al. The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia. Gut Microbes. 2022, 14(1): 2096989

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Microbial Natural Product Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library NO PAINS Compound Library Human Metabolite Library Anti-Liver Cancer Compound Library Antibiotics Library Cyclic Peptide Library Immunology/Inflammation Compound Library

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Keywords

Vancomycin 1404-90-6 Autophagy Microbiology/Virology Antibiotic Antibacterial Inhibitor inhibit Bacterial inhibitor

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