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Vonoprazan

Catalog No. T8388 CAS 881681-00-1

Synonyms: TAK-438 (free base)

Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis

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Vonoprazan, CAS 881681-00-1

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis
Targets&IC50	H+, K+ ATPase (porcine gastric, at pH 6.5):19 nM (IC50)

Synonyms	TAK-438 (free base)
Molecular Weight	345.39
Formula	C17H16FN3O2S
CAS No.	881681-00-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (95.54 mM)

References and Literature

1. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804. 2. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Pediatric Drug Library Bioactive Compounds Library Max FDA-Approved Drug Library ReFRAME Related Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Pantoprazole Rabeprazole sodium Esomeprazole Abscisic Acid Tenatoprazole Ilaprazole sodium hydrate S-Pantoprazole sodium trihydrate Ilaprazole

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vonoprazan 881681-00-1 Membrane transporter/Ion channel Proton pump TAK-438 (free base) GERD Bacterial antisecretory blocker peptic Proton Pump secretion TAK-438 inhibit P-CAB gastroesophageal competitive ulcer gastric potassium disease pump proton TAK 438 inhibitor acid reflux TAK438

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