Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 41.00 | |
200 mg | In stock | $ 65.00 | |
500 mg | In stock | $ 141.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5. |
Targets&IC50 | H+,K+-ATPase:19 nM |
In vitro | The inhibitory activity of Vonoprazan Fumurate was unaffected by ambient pH. The inhibition by Vonoprazan Fumurate was reversible and achieved in a K(+)-competitive manner, quite different from that by lansoprazole. Vonoprazan Fumurate exhibits porcine gastric H+ ,K+-ATPase activity in a concentration-dependent manner[4]. |
In vivo | Vonoprazan Fumurate, at a dose of 4 mg/kg (as the free base) orally, completely inhibited basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats, and its effect on both was stronger than that of lansoprazole. Vonoprazan Fumurate increased the pH of gastric perfusate to a higher value than did lansoprazole or SCH28080, and the effect of Vonoprazan Fumurate was sustained longer than that of lansoprazole or SCH28080[4]. |
Synonyms | TAK-438, TAK 438, Vonoprazan Fumurate, TAK438 |
Molecular Weight | 461.46 |
Formula | C21H20FN3O6S |
CAS No. | 881681-01-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.61 mg/mL (10 mM), Sonification is recommended
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