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Wortmannin

Catalog No. T6283 CAS 19545-26-7

Synonyms: KY12420, Antibiotic, SL2052, PI3K, KY 12420, inhibit, Wortmannin, KY-12420, Autophagy, Polo-like Kinase (PLK), SL 2052, SL-2052, Phosphoinositide 3-kinase, Inhibitor

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.

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Wortmannin, CAS 19545-26-7

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.
Targets&IC50	ATM:150 nM, DNA-PK:16 nM, PI3K:3 nM
In vitro	Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. [3]

Synonyms	KY12420, Antibiotic, SL2052, PI3K, KY 12420, inhibit, Wortmannin, KY-12420, Autophagy, Polo-like Kinase (PLK), SL 2052, SL-2052, Phosphoinositide 3-kinase, Inhibitor
Molecular Weight	428.437
Formula	C23H24O8
CAS No.	19545-26-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 2.1 mg/mL (5 mM)), with gentle warming

DMSO: 21.4 mg/mL (50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Nakanishi S, et al. J Biol Chem, 1992, 267(4), 2157-2163. 1. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy. 2021 Oct;17(10):3030-3047 2. Arcaro A, et al. Biochem J, 1993, 296(Pt 2), 297-301. 2. Ly T T G, Yun J, Ha J S, et al. Inhibitory Effect of Etravirine, a Non-Nucleoside Reverse Transcriptase Inhibitor, via Anterior Gradient Protein 2 Homolog Degradation against Ovarian Cancer Metastasis. International Journal of Molecular Sciences. 2022, 23(2): 944. 3. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969 3. Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026. 4. Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. Journal of Cell Science. 2022 Mar 1;135(5):jcs255026. doi: 10.1242/jcs.255026. Epub 2021 Apr 20. 4. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent[J]. Scientific reports. 2018 Oct 8;8(1):14969. 5. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library

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