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XMD16-5

Catalog No. T3710Cas No. 1345098-78-3

XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is disrupted in breast, prostate and gastrointestinal tumors.

XMD16-5

XMD16-5

Purity: 99.6%
Catalog No. T3710Cas No. 1345098-78-3
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is disrupted in breast, prostate and gastrointestinal tumors.
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
2 mg$51In Stock
5 mg$92In Stock
10 mg$147In Stock
25 mg$237In Stock
50 mg$437In Stock
100 mg$648In Stock
500 mg$1,380In Stock
1 mL x 10 mM (in DMSO)$92In Stock
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Purity:99.6%
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Product Introduction

Bioactivity
Description
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is disrupted in breast, prostate and ga
Targets&IC50
R806Q:77 nM, D163E:16nM
In vitro
XMD16-5 is found to be potent in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.
Kinase Assay
Kinase targets are tested with biochemical enzymatic kinase assays using the SelectScreen Kinase Profiling Service to determine IC50 values. The compounds (XMD16-5) are assayed at 10 concentrations (3-fold serial dilutions starting from 1 μM) at an ATP concentration equal to the ATP Km[1].
Cell Research
293T cells expressing TNK2 are plated in 6-well format at a density of 250,000 cells per well 48 hours prior to treatment. Cells are then treated with a 100 μL of XMD8-87 or XMD16-5 at 5 μmol/L and with 9 1:1 serial dilutions down to ≈10 nmol/L. Two additional samples are treated with DMSO only. Cells are then incubated for 6 hours at 37°C. Protein extraction is accomplished by adding 300 μL of lysis buffer to cells after removing media. Plates are gently shaken for 5 minutes at room temperature. Lysates are collected and cleared of incompletely solubilized material by spinning for 10 minutes at maximum speed in a microcentrifuge. Samples are prepared for SDS-PAGE using the EPage loading buffer.(Only for Reference)
Chemical Properties
Molecular Weight416.48
FormulaC23H24N6O2
Cas No.1345098-78-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (108.05 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (12.01 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4011 mL12.0054 mL24.0108 mL120.0538 mL
5 mM0.4802 mL2.4011 mL4.8022 mL24.0108 mL
10 mM0.2401 mL1.2005 mL2.4011 mL12.0054 mL
DMSO
1mg5mg10mg50mg
20 mM0.1201 mL0.6003 mL1.2005 mL6.0027 mL
50 mM0.0480 mL0.2401 mL0.4802 mL2.4011 mL
100 mM0.0240 mL0.1201 mL0.2401 mL1.2005 mL

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