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AAPK-25

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Purity:97.79%

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COA HPLC HNMR

AAPK-25

Catalog No. T10215Cas No. 2247919-28-2

AAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis. AAPK-25 targets Aurora A, Aurora B, and Aurora C with Kd values ranging from 23-289 nM, and PLK1, PLK2, and PLK3 with Kd values ranging from 55-456 nM. AAPK-25 has antitumor activity.

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$261	In Stock
10 mg	$387	In Stock
25 mg	$649	In Stock
50 mg	$923	In Stock
100 mg	$1,260	In Stock
500 mg	$2,520	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock

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Product Introduction

Bioactivity

Description	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with Kd values ranging from 23-289 nM, a
In vitro	AAPK-25 inhibits HCT-116, Calu6, A549, and MCF-7 cells growth (IC50s: 0.4, 5.3, 11.6, and 2.3 μM). AAPK-25 induces apoptosis as a dose-dependent manner in HCT-116 cell line. AAPK-25 has significantly increased histone H3Ser10 phosphorylation, indicating a markedly mitotic block. AAPK-25 is notably inhibition of the mitotic spindle checkpoint.
In vivo	AAPK-25 enhances the survival rate in the BALB/c nude mice tumor xenograft model.

Chemical Properties

Molecular Weight	442.32
Formula	C21H13Cl2N3O2S
Cas No.	2247919-28-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (113.04 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2608 mL	11.3040 mL	22.6081 mL	113.0403 mL
5 mM	0.4522 mL	2.2608 mL	4.5216 mL	22.6081 mL
10 mM	0.2261 mL	1.1304 mL	2.2608 mL	11.3040 mL
20 mM	0.1130 mL	0.5652 mL	1.1304 mL	5.6520 mL
50 mM	0.0452 mL	0.2261 mL	0.4522 mL	2.2608 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1304 mL

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