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ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $34 | In Stock | |
10 mg | $59 | In Stock | |
25 mg | $128 | In Stock | |
50 mg | $198 | In Stock | |
100 mg | $297 | In Stock | |
200 mg | $442 | In Stock | |
1 mL x 10 mM (in DMSO) | $37 | In Stock |
Description | ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies. |
Targets&IC50 | D4 receptor:12.4 nM(EC50,human), D4 receptor:14.3 nM(EC50, rat), D4 receptor:23.2(EC50, ferret) |
In vitro | A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6[1]. |
In vivo | In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner[1]. |
Molecular Weight | 402.75 |
Formula | C17H22Cl3N5 |
Cas No. | 587870-77-7 |
Smiles | N1(C2=CC=CC=N2)CCN(CC3=NC4=CC=CC=C4N3)CC1.Cl.Cl.Cl |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (248.29 mM) DMSO: 60 mg/mL (148.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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