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ABT 724 trihydrochloride
ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.
Catalog No. T22019Cas No. 587870-77-7
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Purity:99.72%
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ABT 724 trihydrochloride
Catalog No. T22019Cas No. 587870-77-7
ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $34 | In Stock | |
| 10 mg | $59 | In Stock | |
| 25 mg | $128 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $297 | In Stock | |
| 200 mg | $442 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies. |
| Targets&IC50 | D4 receptor:12.4 nM(EC50,human), D4 receptor:14.3 nM(EC50, rat), D4 receptor:23.2(EC50, ferret) |
| In vitro | A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6[1]. |
| In vivo | In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner[1]. |
| Molecular Weight | 402.75 |
| Formula | C17H22Cl3N5 |
| Cas No. | 587870-77-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (248.29 mM) DMSO: 60 mg/mL (148.98 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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