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Acebutolol hydrochloride

🥰Excellent
Catalog No. T1012Cas No. 34381-68-5
Alias Acebutolol HCl

Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.

Acebutolol hydrochloride

Acebutolol hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T1012Alias Acebutolol HClCas No. 34381-68-5
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
Pack SizePriceAvailabilityQuantity
50 mg$42 In Stock
100 mg$48 In Stock
200 mg$61 In Stock
1 mL x 10 mM (in DMSO)$30 In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
In vitro
In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
In vivo
In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
AliasAcebutolol HCl
Chemical Properties
Molecular Weight372.89
FormulaC18H29ClN2O4
Cas No.34381-68-5
SmilesCl.CCCC(=O)Nc1cc(C(=O)C)c(OCC(O)CNC(C)C)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 70 mg/mL (187.72 mM), Sonication is recommended.
H2O: 69 mg/mL (185.04 mM), Sonication is recommended.
DMSO: 50 mg/mL (134.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O/Ethanol
1mg5mg10mg50mg
1 mM2.6818 mL13.4088 mL26.8176 mL134.0878 mL
5 mM0.5364 mL2.6818 mL5.3635 mL26.8176 mL
10 mM0.2682 mL1.3409 mL2.6818 mL13.4088 mL
20 mM0.1341 mL0.6704 mL1.3409 mL6.7044 mL
50 mM0.0536 mL0.2682 mL0.5364 mL2.6818 mL
100 mM0.0268 mL0.1341 mL0.2682 mL1.3409 mL

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