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Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $42 | In Stock | |
100 mg | $48 | In Stock | |
200 mg | $61 | In Stock | |
1 mL x 10 mM (in DMSO) | $30 | In Stock |
Description | Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents. |
In vitro | In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol. |
In vivo | In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol. |
Alias | Acebutolol HCl |
Molecular Weight | 372.89 |
Formula | C18H29ClN2O4 |
Cas No. | 34381-68-5 |
Smiles | Cl.CCCC(=O)Nc1cc(C(=O)C)c(OCC(O)CNC(C)C)cc1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 70 mg/mL (187.72 mM), Sonication is recommended. H2O: 69 mg/mL (185.04 mM), Sonication is recommended. DMSO: 50 mg/mL (134.09 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O/Ethanol
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