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AG-636

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Purity:99.19%

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COA HNMR HPLC

AG-636

Catalog No. T9121Cas No. 1623416-31-8

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.

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Pack Size	Price	Availability
1 mg	$71	In Stock
5 mg	$166	In Stock
10 mg	$273	In Stock
25 mg	$555	In Stock
50 mg	$798	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$182	In Stock

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Product Introduction

Bioactivity

Description	AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
In vitro	AG-636, in cancer cell lines of hematologic versus solid tumor origin.?Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model
In vivo	AG-636 (10-100 mg/kg ;?oral gavage;?twice daily;?for 14 days) treatment results in robust tumor growth inhibition in the OCILY19 DLBCL tumor xenograft model

Chemical Properties

Molecular Weight	343.38
Formula	C21H17N3O2
Cas No.	1623416-31-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.25 mg/mL (91.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9122 mL	14.5611 mL	29.1223 mL	145.6113 mL
5 mM	0.5824 mL	2.9122 mL	5.8245 mL	29.1223 mL
10 mM	0.2912 mL	1.4561 mL	2.9122 mL	14.5611 mL
20 mM	0.1456 mL	0.7281 mL	1.4561 mL	7.2806 mL
50 mM	0.0582 mL	0.2912 mL	0.5824 mL	2.9122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc