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AR7
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Purity:99.52%
AR7
Catalog No. T3955Cas No. 80306-38-3
AR7 is a retinoic acid receptor α (RARα) antagonist.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $63 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $213 | In Stock | |
| 50 mg | $347 | In Stock | |
| 100 mg | $578 | In Stock | |
| 200 mg | $798 | In Stock | |
| 500 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $68 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AR7 is a retinoic acid receptor α (RARα) antagonist. |
| In vitro | Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA. The antagonistic effect of the retinoid derivatives likely results from a combination of tight binding to RARα and high stability. |
| Molecular Weight | 257.71 |
| Formula | C15H12ClNO |
| Cas No. | 80306-38-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 5.5 mg/mL (21.34 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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