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Atipamezole
🥰Excellent
Catalog No. T6766Cas No. 104054-27-5
Alias MPV 1248, Antisedan
Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
Atipamezole
🥰Excellent
Purity: 99.76%
Catalog No. T6766Alias MPV 1248, AntisedanCas No. 104054-27-5
Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $48 | In Stock | |
| 10 mg | $68 | In Stock | |
| 25 mg | $143 | In Stock | |
| 50 mg | $252 | In Stock | |
| 100 mg | $378 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
| Targets&IC50 | α2-adrenoceptor antagonist:1.6 nM（Ki） |
| In vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
| In vivo | Atipamezole is well-tolerated in rodents and exhibits modest cardiovascular effects (0.01–1 mg/kg, i.v.) in anesthetized, normotensive rats. It is frequently used by veterinarians to reverse sedation or anesthesia in animals. Atipamezole enhances sexual activity in rats and monkeys and increases pain-related responses in animals with sustained nociception by blocking noradrenergic feedback inhibition of pain. At low doses, it improves alertness, selective attention, planning, learning, and recall in experimental animals, although not necessarily affecting short-term working memory[1]. |
| Alias | MPV 1248, Antisedan |
| Molecular Weight | 212.29 |
| Formula | C14H16N2 |
| Cas No. | 104054-27-5 |
| Smiles | C(C)C1(CC=2C(C1)=CC=CC2)C3=CN=CN3 |
| Relative Density. | 1.115 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 39 mg/mL (183.71 mM), Sonication is recommended. Ethanol: 39 mg/mL (183.71 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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