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Betaxolol hydrochloride

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Catalog No. T0226Cas No. 63659-19-8
Alias SL 75212 HCl, Betaxolol HCl

Betaxolol hydrochloride (SL 75212 HCl) is a cardioselective beta-blocker used in the treatment of hypertension.Betaxolol hydrochloride has not been linked to instances of clinically apparent drug induced liver injury.

Betaxolol hydrochloride

Betaxolol hydrochloride

🥰Excellent
Purity: 99.56%
Catalog No. T0226Alias SL 75212 HCl, Betaxolol HClCas No. 63659-19-8
Betaxolol hydrochloride (SL 75212 HCl) is a cardioselective beta-blocker used in the treatment of hypertension.Betaxolol hydrochloride has not been linked to instances of clinically apparent drug induced liver injury.
Pack SizePriceAvailabilityQuantity
25 mg$32In Stock
50 mg$46In Stock
100 mg$77In Stock
200 mg$97In Stock
500 mg$162In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
Betaxolol hydrochloride (SL 75212 HCl) is a cardioselective beta-blocker used in the treatment of hypertension.Betaxolol hydrochloride has not been linked to instances of clinically apparent drug induced liver injury.
Targets&IC50
β1-adrenoceptor:6 μM
In vitro
Betaxolol's constituents are capable of partially inhibiting changes induced by NMDA and hypoxia/glucose deficiency. Intraperitoneal injection of Betaxolol in rats during focal ischemia and before reperfusion injury effectively mitigates alterations in calretinin and ChAT immunoreactivity, and also prevents the decline of b-wave amplitude.
In vivo
At a concentration of 10 µM, Betaxolol significantly inhibits the release of LDH (lactate dehydrogenase) induced by glutamate esters. Additionally, 100 µM Betaxolol effectively prevents the release of LDH in cortical tissue caused by hypoxia. Betaxolol offers protective effects on retinal neurons and attenuates the influx of ^(45)Ca2+ induced by NMDA (N-methyl-D-aspartate) when β-adrenergic receptor agonists are ineffective.
Cell Research
Dissociated cortical cells from 16–18-day-old fetal rats are grown, in 35 mm dishes, in DMEM supplemented with L-glutamine (4 mM), glucose (6 g/L), penicillin (100 U/mL), streptomycin (100 μg/mL) and 10% hormonal supplemented medium consisting of transferrin (1 mg/mL), insulin (250 μg/mL) putrescine (600 μM), sodium selenite (0.3 μM), progesterone (0.2 μM) and estradiol (0.1 pM) for 7 days in an atmosphere of 5% CO2/95% O2 at 37 °C. The cultures are then transferred to a culture medium which lacks the hormonal supplemented medium. L-glutamate is added to the medium and incubated for a further 4 hours under normoxic conditions. Betaxolol are added to the cultures at the same time as L-glutamate. In other experiments the cultures are subjected to anoxic conditions, 95% N2/5% CO2, for 5 hours at 37 °C. Betaxolol is added prior to anoxia. Reoxygenation is then achieved by replacing the cells in normoxic conditions (95% O2/5% CO2) for 3 hours. Cellular injury is assessed by measuring lactate dehydrogenase (LDH) release into the cell culture supernatant after hypoxia/reoxygenation or glutamate exposure. LDH activity is assayed spectrophotometrically by following NADH metabolism for 2 minutes at 340 nm.(Only for Reference)
AliasSL 75212 HCl, Betaxolol HCl
Chemical Properties
Molecular Weight343.89
FormulaC18H30ClNO3
Cas No.63659-19-8
SmilesCl.CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (145.4 mM)
H2O: 29.08 mM
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.9079 mL14.5395 mL29.0791 mL145.3953 mL
5 mM0.5816 mL2.9079 mL5.8158 mL29.0791 mL
10 mM0.2908 mL1.4540 mL2.9079 mL14.5395 mL
20 mM0.1454 mL0.7270 mL1.4540 mL7.2698 mL
DMSO
1mg5mg10mg50mg
50 mM0.0582 mL0.2908 mL0.5816 mL2.9079 mL
100 mM0.0291 mL0.1454 mL0.2908 mL1.4540 mL

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