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Carmofur

Carmofur
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
Catalog No. T1307Cas No. 61422-45-5
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Purity:99.48%
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Carmofur

Catalog No. T1307Alias HCFUCas No. 61422-45-5

Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
50 mg$34In Stock
100 mg$48In Stock
200 mg$59In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Product Introduction

Bioactivity
Description
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
Targets&IC50
AC:29 ± 5 nM
In vitro
Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity. [1]
AliasHCFU
Chemical Properties
Molecular Weight257.26
FormulaC11H16FN3O3
Cas No.61422-45-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (155.48 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 10 mg/mL (38.87 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.8871 mL19.4356 mL38.8712 mL194.3559 mL
5 mM0.7774 mL3.8871 mL7.7742 mL38.8712 mL
10 mM0.3887 mL1.9436 mL3.8871 mL19.4356 mL
20 mM0.1944 mL0.9718 mL1.9436 mL9.7178 mL
DMSO
1mg5mg10mg50mg
50 mM0.0777 mL0.3887 mL0.7774 mL3.8871 mL
100 mM0.0389 mL0.1944 mL0.3887 mL1.9436 mL

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