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Ceefourin 1

Ceefourin 1
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Purity:98.4%
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Ceefourin 1

Catalog No. T8596Cas No. 315702-40-0
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$36In Stock
2 mg$51In Stock
5 mg$80In Stock
10 mg$122In Stock
25 mg$263In Stock
50 mg$409In Stock
100 mg$596In Stock
1 mL x 10 mM (in DMSO)$111In Stock
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Product Introduction

Bioactivity
Description
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
In vitro
Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates, yet are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein;?BCRP) and MRP1 (multidrug resistance protein 1;?ABCC1).?Both compounds are more potent MRP4 inhibitors in cellular assays than the most widely used inhibitor, MK-571, requiring lower concentrations to effect a comparable level of inhibition.?Furthermore, Ceefourin 1 and Ceefourin 2 have low cellular toxicity, and high microsomal and acid stability.
Chemical Properties
Molecular Weight294.42
FormulaC11H10N4S3
Cas No.315702-40-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 11 mg/mL (37.36 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3965 mL16.9825 mL33.9651 mL169.8254 mL
5 mM0.6793 mL3.3965 mL6.7930 mL33.9651 mL
10 mM0.3397 mL1.6983 mL3.3965 mL16.9825 mL
20 mM0.1698 mL0.8491 mL1.6983 mL8.4913 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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