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COR659

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Purity:99.56%

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COA HPLC

COR659

Catalog No. T36520Cas No. 544450-68-2

COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor.

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Pack Size	Price	Availability
1 mg	$81	In Stock
2 mg	$118	In Stock
5 mg	$197	In Stock
10 mg	$313	In Stock
25 mg	$569	In Stock
50 mg	$793	In Stock
100 mg	$1,090	In Stock
500 mg	$2,230	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Product Introduction

Bioactivity

Description	COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor[3]. COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1].COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1]. [1]. Paola Maccioni, et al. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA B and cannabinoid CB 1 receptors. Psychopharmacology (Berl). 2017 Sep;234(17):2525-2543. [2]. Francesca Ferlenghi, et al. The GABA B receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Eur J Pharm Sci. 2020 Dec 1;155:105544. [3]. Paola Maccioni, et al. Anti-addictive properties of COR659 - Additional pharmacological evidence and comparison with a series of novel analogues. Alcohol. 2019 Mar;75:55-66.
In vitro	COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor[3].
In vivo	COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats[1].COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats[2]. Animal Model: Male sP and Wistar rats[1].

Chemical Properties

Molecular Weight	337.82
Formula	C16H16ClNO3S
Cas No.	544450-68-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (98.66 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9602 mL	14.8008 mL	29.6016 mL	148.0078 mL
5 mM	0.5920 mL	2.9602 mL	5.9203 mL	29.6016 mL
10 mM	0.2960 mL	1.4801 mL	2.9602 mL	14.8008 mL
20 mM	0.1480 mL	0.7400 mL	1.4801 mL	7.4004 mL
50 mM	0.0592 mL	0.2960 mL	0.5920 mL	2.9602 mL

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