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(S)-CPI203
Catalog No. T6026Cas No. 1446144-04-2
Alias CPI203, CPI 203
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
(S)-CPI203
Catalog No. T6026Alias CPI203, CPI 203Cas No. 1446144-04-2
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $53 | In Stock | |
| 10 mg | $86 | In Stock | |
| 25 mg | $188 | In Stock | |
| 50 mg | $298 | In Stock | |
| 100 mg | $472 | In Stock | |
| 200 mg | $659 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $56 | In Stock |
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Purity:99.36%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4). |
| Targets&IC50 | BRD4:37 nM |
| In vitro | CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro. [1] CPI203 exerts a cytostatic effect in all the 9 MCL cell lines analyzed with GI50 ranging from 0.06 to 0.71 μM, with low cytotoxicity in normal PBMCs from healthy donors. Furthermore, lenalidomide and CPI203, by targeting IRF4 and MYC, efficiently activates the cell death program in MCL cells resistant to bortezomib. [2] |
| Kinase Assay | BRD4 α-screen assay: The BRD4 α-screen assay is a proximity-based assay using a tetraacteylated H4 peptide and the isolated bromodomain 1 of human BRD4. IC50 values are calculated using a 10-point serial dilution of BET inhibitor. |
| Alias | CPI203, CPI 203 |
| Molecular Weight | 399.9 |
| Formula | C19H18ClN5OS |
| Cas No. | 1446144-04-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (125.03 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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